Reversing Alzheimer's — The Forgotten Causes and Cures Massive Pharma Buried
Alzheimer’s dementia is without doubt one of the most important medical challenges our nation faces (e.g., it locations an unbelievable burden upon society, e.g., final 12 months it was estimated to value the USA 360 billion {dollars}).1 But, regardless of spending billions for analysis annually, cures stay elusive, one thing many imagine outcomes from the flawed perception that eliminating the amyloid plaques related to Alzheimer’s will repair it. In flip, as I confirmed right here:
• Many years of amyloid therapies have by no means produced a helpful remedy.
• The latest “breakthrough” amyloid-eliminating monoclonal antibodies, at greatest barely gradual the development of Alzheimer’s whereas concurrently inflicting a number of unwanted side effects, together with mind bleeding and swelling in over 1 / 4 of recipients.
• All the amyloid business rests upon a fraudulent research nobody wished to retract as a result of how a lot was invested within the amyloid speculation.
In brief, the cash behind this juggernaut has brought on analysis into the actual causes of Alzheimer’s to be suppressed. For instance, right here I highlighted how coconut oil MCTs (safely) do greater than any of the pricey amyloid medicine — but nearly nobody is aware of this.2
Dale Bredesen’s Discovery
Many are additionally unaware of a 2022 research that ought to have revolutionized your complete Alzheimer’s subject:3
That protocol was based mostly on Dale Bredesen’s insightful realizations that:4
• Amyloid protein is a protecting mechanism the mind makes use of to guard itself from stressors that endanger mind tissue — making makes an attempt to deal with Alzheimer’s by eliminating it are doomed to fail.
• The mind is designed to have the ability to adapt to the wants of life, so it’s all the time creating or pruning neural connections and mind cells. Alzheimer’s outcomes from the lack of alerts that maintain mind cells and the dismantling of neural connections, outweighing the formation of latest neural connections, a course of that progressively compounds over the a long time.
• Fairly than there being one sort of Alzheimer’s, there are literally a number of varieties that every require totally different remedy approaches.
Be aware: Past the 2022 trial, which confirmed individually focused therapies might shift the mind’s momentum from neurological degeneration to regrowth,5 a 2018 report of 100 sufferers from quite a few suppliers additionally confirmed it handled Alzheimer’s,6 as did a 2024 case sequence of sufferers with outstanding outcomes,7 and there are actually neurologists across the nation administering Bredesen’s protocol with success.
The 6 Sorts of Alzheimer’s Illness
As this understanding of Alzheimer’s has produced tangible outcomes, this means the causes of Alzheimer’s that Bredesen recognized certainly play a key position within the illness — notably since many different datasets corroborate their contribution to Alzheimer’s. They’re as follows:
• Sort 1 — Inflammatory — This manner is pushed by extreme irritation, usually metabolic or infectious in nature. Continual activation of the immune system — as a result of components equivalent to insulin resistance, a poor food plan, a leaky intestine, or latent infections — leads the mind to interact in protecting downsizing by eradicating synapses and neurons which might be much less important for rapid survival. It usually presents with basic Alzheimer’s reminiscence loss and sometimes develops within the sixties to seventies.
• Sort 1.5 — Glycotoxic — This subtype arises from insulin resistance and chronically elevated blood sugar. It results in each inflammatory and trophic deficiencies, and is pushed by glycotoxicity and the buildup of superior glycation finish merchandise (AGEs), which impair mobile operate and synaptic integrity. It sometimes seems within the late fifties to sixties.
Be aware: Chronically elevated insulin promotes amyloid formation, because the enzyme the physique makes use of to interrupt down insulin is similar enzyme it makes use of to interrupt down amyloid plaques.8
• Sort 2 — Atrophic — This kind is brought on by deficiencies in key vitamins, hormones, and different components that present trophic (supportive) alerts to mind cells, which then triggers the same downsizing mechanism seen in Sort 1. Sort 2 tends to emerge a couple of decade later than Sort 1.
Be aware: We discover these dietary deficiencies may result from poor circulation lowering present vitamins reaching mind tissue, and therefore usually concentrate on bettering circulation fairly than prolonged supplementation.
• Sort 3 — Poisonous — This subtype outcomes from publicity to poisonous substances that immediately harm neurons. Widespread culprits embody biotoxins, persistent infections, heavy metals, and industrial or family chemical compounds. Causative infections (mentioned additional right here) embody Cytomegalovirus, Human Herpesvirus 1 or 6, Lyme illness, dental micro organism that may journey to the mind (e.g., P. gingivalis), and numerous fungal infections (as mildew toxins are infamous for inflicting cognitive impairment in any respect ages).
Sort 3 uniquely causes widespread and infrequently unpredictable neuronal demise, happens earlier in life — usually between the 40’s and sixties — and is much less strongly related to genetic threat components. Cognitive decline on this sort is incessantly accompanied by psychiatric signs, sensory adjustments, or government dysfunction (e.g., problem with math, group, government duties), fairly than the extra basic early Alzheimer’s reminiscence loss.
Be aware: Among the most vital neurotoxins to keep away from are prescribed drugs, and after I meet aged people who’ve preserved their psychological readability, many report having largely averted prescribed drugs all through their lives.
Among the commonest problematic drugs for mind well being embody sure hypertension drugs (as a result of they decrease cerebral perfusion), statins (as they inhibit the manufacturing of compounds important for mind operate), acid reflux disorder drugs (which intervene with the absorption of important mind vitamins — making it crucial for everybody to have satisfactory abdomen acid), antidepressants, antipsychotics, benzodiazepines, antihistamines (since, like many sleeping capsules, they block restorative sleep), and anticholinergics (equivalent to these prescribed for incontinence).
• Sort 4 — Vascular — On this kind, persistent restriction of cerebral blood circulation from present vascular ailments results in gradual neuronal harm and cognitive decline. Sort 4 usually seems within the seventies or past) and should overlap with different subtypes. It tends to have an effect on processing pace, consideration, and government operate fairly than reminiscence alone.
Be aware: Fast cognitive decline incessantly adopted COVID vaccination, and considerably overlapped with this kind.
• Sort 5 — Traumatic — Extreme head traumas or repeated concussions (e.g., in skilled soccer gamers)9 set off a cascade of persistent degenerative processes that trigger cognitive and emotional dysfunction to seem years or a long time after the accidents — making it crucial to forestall these accidents and search applicable remedy when head traumas occur.
Be aware: There are a number of causes of dementia, a lot of that are incessantly (roughly half the time)10,11 misdiagnosed as Alzheimer’s. In lots of instances, these reply to the identical remedies which reverse Alzheimer’s, however in different instances, require totally different remedies.
Wholesome Fluid Circulation
Many practitioners I do know who’ve efficiently handled dementia with quite a lot of strategies (listed right here) all concluded it resulted from impairments of blood circulation to the mind and lymphatic or venous drainage from it. For instance:
• Zeta potential offers the disperse pressure which retains constituents inside fluids from agglomerating and clogging the circulatory vessels (e.g., vaccines incessantly set off detectable microstrokes by inflicting blood cells to clump collectively).
In a myriad of sicknesses, we discover restoring the physiologic zeta potential (mentioned right here) is pivotal for restoring well being — notably these related to getting old, as zeta potential worsens with age (as a result of declining kidney operate). In flip, one of many physicians who impressed my medical path did so as a result of his observe revolved round treating zeta potential and he repeatedly achieved important cognitive enhancements for his getting old sufferers.
Be aware: Impaired zeta potential can even trigger proteins (e.g., amyloids) to misfold and clump collectively.
• China not too long ago developed a surgical procedure (detailed right here) to extend the lymphatic drainage from the mind. Attributable to its low value, it’s being quickly adopted nationwide. In parallel, an American process was developed to extend venous drainage from the pinnacle and reported to enormously enhance a number of sclerosis together with different persistent neuroimmune problems (which distant colleagues witnessed).
Be aware: I’ve seen many different circulatory enhancing therapies (listed right here) additionally enhance cognitive decline and dementia.
Moreover, past blood being important for neuronal survival, the correct clearance of waste merchandise from the mind is as effectively. Sadly, as a result of how restricted area is for the mind throughout the cranium, sturdy lymphatic vessels don’t exist, and as a substitute, lymphatic drainage is created by astrocytes creating short-term lymphatic vessels round blood vessels throughout deep sleep.
This method, in flip, is extremely susceptible to disruption, and quite a few research have now linked impaired glymphatic drainage to dementia12 (e.g., TBIs impair glymphatic drainage13 and satisfactory glymphatic drainage is required to remove amyloid from the mind)14 — which doubtless impressed the Chinese language surgical process for dementia.
As a result of fragility of this method, disruptions are fairly consequential (e.g., a poor zeta potential thickens and slows the drainage of glymphatic fluids). For instance, as glymphatic drainage solely happens throughout deep sleep, insufficient sleep has been extensively linked to dementia15 (e.g., one research discovered sleep disruption elevated dementia by 104%,16 one other by 22% to 50%,17 and a 3rd noticed a 139% improve18 — together with one other discovering that sleep disruption brought on a 71% improve in delicate cognitive impairment).19
Likewise, disrupted sleep was not too long ago proven to speed up the buildup of amyloid plaques,20 and in one other research, to mitigate the cognitive impairment created by Alzheimer’s plaques.21 Sadly, the pathologic proteins in Alzheimer’s have been proven to immediately disrupt restorative sleep22 and to remove the power to acknowledge one is affected by impaired sleep23 — demonstrating why it’s so vital to revive your wholesome sleep earlier than the momentum of dementia has entrenched itself.
Be aware: Sleeping capsules block restorative sleep, and have quite a lot of points (e.g., they make customers 2 to five instances as more likely to die24,25). Relating to dementia, a number of research have discovered that sleeping capsules improve the chance of it by 17% to 84%.26,27,28,29
The Lifetime of Cells and Neuroplasticity
One of many issues I frequently marvel at about nature shouldn’t be solely the power of a species to genetically adapt to its atmosphere, however the inherent adaptability every organism has inside its personal lifespan to adapt to its personal atmosphere. Throughout the human physique, there are a lot of programs which might be designed to alter based mostly on the wants of 1’s atmosphere (e.g., for this reason weight coaching creates bigger muscle tissues), and among the many most adaptable is the nervous system.
So, at any given second, neural circuits that assist sure actions are bolstered, whereas different circuits are pruned and ultimately disabled, a course of that permits the nervous system to adapt to the complicated wants of its atmosphere. On the similar time, many complicated neurological and psychiatric problems come up from a momentum being established the place dysfunctional neurological circuits perpetually reinforce themselves.
For these problems to be handled, momentum should as a substitute be constructed round a wholesome circuit (for these , that is the very best guide I’ve seen on the topic).30 This momentum is a key cause why it’s so vital to have wholesome thought patterns and recurrently actively train your mind (one other core part of applications for stopping Alzheimer’s).
If you happen to do the alternative (e.g., watch TV all day), dysfunctional patterns can turn into established habits, whereas neurological harm happens as components of the mind you want however underneath make the most of are pruned away.
A key means the mind accomplishes this adaptability is by eliminating neurons which might be not deemed important. Bredesen’s concept of Alzheimer’s is that it outcomes from the stability between preserving and eliminating neurons being shifted in the direction of eradicating them,31 which inevitably will lead to cognitive decline.
Inside Bredesen’s mannequin, the amyloid protein performs a key position on this course of,32 as when it’s initially shaped because the amyloid precursor protein (APP), it will possibly then be cut up into two or 4 components. Whether it is divided into two components, these components defend the neurological operate within the mind. Compared, whether it is divided into 4 components, the neurological operate of the mind is broken, and mind cells are eradicated.
Curiously, its splitting into 4 components causes future APPs to be cut up into 4 components as effectively (making a downward spiral). Consequently, Brenden’s strategy focuses on regaining a wholesome momentum in the direction of the two-part splitting whereas additionally offering the alerts cells throughout the physique require to outlive.
The Cell Hazard Response
When cells are uncovered to exterior stressors, they usually enter a primitive defensive metabolic cycle the place they partially or absolutely “flip off” (e.g., mitochondrial respiration and protein synthesis throughout the cell decline) to guard themselves. Many persistent ailments, in flip, end result from cells being trapped on this degenerative cycle (which regularly results in cell demise) fairly than exiting it and resuming their regular operate. Likewise, many therapies in regenerative medication work by eradicating cells from this frozen metabolic state.
Due to this, many complicated sicknesses (e.g., COVID vaccine accidents, fibromyalgia, or autism) can solely be handled if the underlying set off for the cell hazard response is eliminated. Then a regenerative remedy is offered which alerts cells to exit the CDR. Equally:
“The precept that blocking protein synthesis prevents long-term reminiscence storage was found a few years in the past. With age, there’s a marked decline of protein synthesis within the mind that correlates with defects in correct protein folding. Accumulation of misfolded proteins can activate the built-in stress response (ISR), an evolutionary conserved pathway that decreases protein synthesis. On this means, the ISR could have a causative position in age-related cognitive decline.”
In flip, a lot as remedies for the CDR usually facilitate dementia remedy, therapies that inhibit the ISR have been discovered to revive the construction and performance of mind cells and enhance quite a lot of age-related reminiscence deficits.33,34
DMSO
Dimethyl sulfoxide has quite a lot of distinctive therapeutic properties that enable it to deal with quite a lot of ailments (e.g., it’s miraculous for strokes and mind accidents), and within the 12 months since I started publicizing this forgotten remedy, I’ve obtained 1000’s of outstanding reviews of it treating quite a few “incurable sicknesses.”
A lot of this outcomes from DMSO’s potential to revive regular circulation, defend cells from deadly stressors, and revive shocked cells trapped within the CDR. As such, for the reason that begin of the sequence, along with receiving many reviews from readers who saved themselves or a liked one from a disabling stroke with DMSO, many have additionally shared tales like this:
“My uncle’s spouse has dementia and has been unable to talk for over a 12 months.35 My mother not too long ago visited them and informed them about DMSO. He started to present his spouse DMSO orally. After two weeks she started to speak once more.”
Quite a few research (detailed right here) have corroborated DMSO’s potential to deal with dementia. These embody:
• When cerebral blood circulation was completely diminished in rats, one research discovered DMSO prevented the neuronal and reminiscence loss that in any other case resulted,36 whereas one other discovered DMSO given afterwards handled it.37,38 Related advantages have additionally been seen after Alzheimer’s was induced by injecting toxins into the mind,39,40 Likewise, in mice (or nematodes) engineered to develop Alzheimer’s, DMSO has been repeatedly proven to forestall the anticipated neurological harm.41,42,43
• DMSO has additionally been proven44 to forestall the neuronal harm from experimentally induced Parkinson’s and protect the cognitive operate of mice bred to quickly develop extreme degeneration of the cerebellum and brainstem.45,46
Be aware: IV DMSO is without doubt one of the few therapies I’ve come throughout which might halt Parkinson’s. To some extent oral DMSO helps as effectively (e.g., see this reader’s remark).47
• DMSO has additionally been proven to deal with scrapie (a neurodegenerative prion illness from irregular protein aggregates) in hamsters,48 to extend the exercise of ALP the intercellular enzyme which eliminates mobile waste (together with misfolded proteins),49 and in a lot of research, to deal with amyloidosis (pathologic accumulations of pathologic proteins.
In people:
• 18 sufferers with possible Alzheimer’s after three months, DMSO brought on a major enchancment in reminiscence, focus, communication, and orientation to time and area.50
• In 104 aged adults with natural mind illness from the widespread causes (e.g., strokes, atherosclerosis, Parkinson’s, or head accidents), DMSO enormously improved their psychic and somatic operate.51
• In 100 sufferers with cerebrovascular ailments CVD, a lot of whom have been senile, over 50 days DMSO brought on nearly all to have a major enchancment of their CVD, together with important enhancements in temper, mobility, and speech.52
Conclusion
Medication revolves round discovering distinctive molecular targets for which illness particular remedies will be patented. Sadly, this mannequin incessantly fails in persistent sicknesses, resulting in grotesque conditions just like the one described right here, the place pure therapies, which might handle the precise causes of devastating sicknesses are sidelined to guard every illness’s profitable “remedy” market.
This wants to alter, and for the primary time in my lifetime, because of MAHA, the political will eventually exists to start addressing the actual explanation why there continues to be a lot persistent sickness in our society. The chance to make cognitive decline not an inevitable facet of getting old is lastly right here — if we dare to grab it!
Creator’s Be aware: That is an abridged model of an extended article which discusses the precise causes and coverings for Alzheimer’s illness and the cognitive decline which precedes it. That article, together with extra hyperlinks and references, will be learn right here. Moreover, a companion article on how DMSO treats neurological accidents (e.g., strokes, mind hemorrhages, traumatic mind accidents, spinal paralysis, and developmental delay) will be learn right here.
A Be aware from Dr. Mercola In regards to the Creator
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I recognize AMD’s distinctive perception on a variety of subjects and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance traces treating sufferers. To seek out extra of AMD’s work, you’ll want to take a look at The Forgotten Facet of Medication on Substack.
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