The Nice Alzheimer’s Rip-off and the Confirmed Cures They’ve Buried for Billions

Drugs is strongly biased in direction of adopting biochemical fashions of illness as this facilitates pricey therapeutics being developed for every illness and therefore sustains the medical business. Sadly, in lots of circumstances, the biochemical method to illness, at finest, can handle signs, and because of this, many circumstances stay “incurable” whereas non-patentable pure therapies that may remedy them languish in obscurity.

That’s why, regardless of spending an ever growing amount of cash on Alzheimer’s analysis (e.g., the NIH spent 2.9 billion in 2020 and three.9 billion in 2024¹), we’ve nonetheless did not make any actual progress on the illness. That is notably exceptional given the huge prices to the nation (e.g., final yr Alzheimer’s was estimated to price america 360 billion {dollars}²) and the even larger social prices that accompany it.

The Amyloid Juggernaut

In 1906, plaques (of amyloid) within the mind have been recognized as the reason for Alzheimer’s illness. Because the years have passed by, nearly all of analysis for treating Alzheimer’s illness has been focused at eliminating these plaques. Sadly, to cite a 2022 article:³

“Tons of of scientific trials of amyloid-targeted therapies have yielded few glimmers of promise, nonetheless; solely the underwhelming Aduhelm has gained FDA approval. But Aβ nonetheless dominates analysis and drug growth. NIH spent about $1.6 billion on initiatives that point out amyloids on this fiscal yr, about half its general Alzheimer’s funding.

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Scientists who advance different potential Alzheimer’s causes, comparable to immune dysfunction or irritation, complain they’ve been sidelined by the ‘amyloid mafia.’ Forsayeth says the amyloid speculation grew to become ‘the scientific equal of the Ptolemaic mannequin of the Photo voltaic System,’ through which the Solar and planets rotate round Earth.”

Word: Continuously, when a defective paradigm fails to clarify the illness it claims to handle, quite than admit the paradigm is flawed, its adherents will label every conflicting piece of proof as a paradox (e.g., the French “paradox” disproves the notion ldl cholesterol causes coronary heart illness⁴) and dig deeper and deeper till they’ll discover one thing to proceed propping up their ideology (e.g., ldl cholesterol lowering statins present virtually no profit for coronary heart illness whereas having important unwanted side effects but proceed being pushed on sufferers).

The constant failure of the amyloid mannequin to remedy Alzheimer’s regularly invited growing skepticism in direction of it, which resulted in an increasing number of scientists learning various fashions of the illness. Earlier than lengthy, they discovered different components performed a much more important position in inflicting the illness (e.g., persistent irritation), and by 2006, this angle appeared poised to vary the course of Alzheimer’s analysis.

In response, the amyloid proponents pivoted to defending their failed speculation was due to not amyloid clumps, however quite poisonous components of it (oligomers) and a Nature 2006 paper appeared which recognized a beforehand unknown poisonous oligomer, Aβ*56, and supplied proof that it prompted dementia in rats.⁵

This paper cemented each the amyloid beta and poisonous oligomer hypotheses (because it supplied the proof many adherents to the idea had been ready for) and quickly grew to become one of the cited works within the discipline of Alzheimer’s analysis. Its authors rose to tutorial stardom, produced additional papers validating their preliminary speculation, and billions extra have been invested by each the NIH and the pharmaceutical business in analysis of the amyloid and poisonous oligomer speculation.

It must be famous that some have been skeptical of their findings and likewise have been unable to duplicate this information, however not often had a voice within the debate:

“The spotty proof that Aβ*56 performs a task in Alzheimer’s had [long] raised eyebrows.⁶ Wilcock has lengthy doubted research that declare to make use of ‘purified’ Aβ*56. Such oligomers are notoriously unstable, changing to different oligomer varieties spontaneously. A number of varieties could be current in a pattern even after purification efforts, making it laborious to say any cognitive results are on account of Aβ*56 alone, she notes — assuming it exists.

In truth, Wilcock and others say, a number of labs have tried and failed to seek out Aβ*56, though few have printed these findings. Journals are sometimes bored with detrimental outcomes, and researchers could be reluctant to contradict a well-known investigator.”

The Amyloid Scandal

On the finish of 2021, a neuroscientist doctor was employed by buyers to judge an experimental Alzheimer’s drug and found indicators that its information consisted of doctored Western Blots (and due to this fact faulty assessments of what oligomers have been current inside analysis topics’ brains).⁷ As he explored the subject additional, he found different papers inside the Alzheimer’s literature had been flagged for holding doctored Western Blots.

Word: Western blots, used to check for proteins, are one of many few simply detectable types of analysis fraud (e.g., we found Pfizer submitted faux Western blots to regulators to “show” their vaccine labored). Regrettably, much more undetectable fraud exists all through the scientific literature (e.g., impartial researchers evaluating regulatory submissions found Pfizer additionally submitted doctored information on the place the COVID vaccine is distributed within the physique⁸).

Earlier than lengthy, the neuroscientist seen three of these suspect papers had been printed by the identical creator and determined to research the creator’s different publications. This led him to the seminal 2006 Alzheimer’s publication, which contained clear indicators of fraud.⁹

As investigation then uncovered 20 doctored papers written by the creator, 10 of which pertained to Aβ*56 (together with a co-researcher testifying to earlier scientific misconduct by the creator).

The Amyloid Trade

One of many exceptional issues about this monumental fraud was how little was completed about it. For instance, the NIH was notified in January 2022, but in Could 2022, past nothing being completed, the NIH gave the suspect researcher a coveted $764,792 analysis grant (signed off by one other one of many authors of the 2006 paper¹⁰).

In July 2022, Science printed an article exposing the incident and the clear fraud that had occurred.¹¹ Regardless of this, the researcher was allowed to stay in his place as a tenured medical college professor.¹² It was not till June 2024 that the 2006 article was retracted on the request of the authors¹³ — all of whom denied being at fault and insisted the doctored pictures had not affected the article’s conclusions.

Ultimately, on January 29, 2025, throughout his affirmation listening to, RFK cited the paper for instance of the institutional fraud and wasted tax {dollars} inside the NIH, and some days later, the suspect researcher introduced his resignation from the medical college professorship (whereas nonetheless sustaining his innocence).¹⁴

This odd habits (e.g., the medical discipline continues to insist the confirmed fraud has not disproven the Amyloid speculation) possible outcomes from how a lot cash is at stake — past the analysis {dollars}, roughly 7 million adults have Alzheimer’s — equating to tons of of billions in potential (Medicare funded) gross sales annually.¹⁵

The Failed Amyloid Medication

Not too long ago, a monoclonal antibody that made immune cells goal amyloid demonstrated restricted success in treating Alzheimer’s — which was embraced as revolutionary by the medical group, the pharmaceutical business, and drug regulators. In flip, the primary new drug acquired accelerated approval (which the FDA proudly introduced).¹⁶ The second then acquired a quiet backdoor approval (because of the immense controversy surrounding the primary),¹⁷ and the third was partially authorised a yr and a half later.¹⁸

Annually, JP Morgan (Chase Financial institution) hosts a personal convention for pharmaceutical buyers that units the tone for all the business. In 2023, its focus (lined intimately right here) was on the unimaginable profitability of the brand new Alzheimer’s medicine and the GLP-1s like Ozempic (which the FDA has additionally relentlessly promoted). Most remarkably, the (extensively seen as corrupt) FDA commissioner was a keynote speaker, and some days earlier than the convention, had enacted the second backdoor approval.

Nonetheless, regardless of the rosy footage painted across the medicine (which every attacked completely different facets of amyloids), they have been extremely controversial as:

The second monoclonal antibody (which focused amyloid precursors) had a considerably higher danger profit profile²² (solely 21% skilled mind bleeding and swelling on account of decreased concentrating on of secure amyloid plaques), and 26.4% discount within the development of Alzheimer’s was detected within the trial (which for context, translated to a 0.45 discount on a scale the place a discount of at the least 1 to 2 factors is required to create an impression which is in any method significant for a affected person).

The third monoclonal (which focused amyloid plaques regarded as extra pathologic)²³ was additionally contested because it prompted 36.8% of recipients to develop mind bleeding or swelling, like the opposite amyloid drugs, often prompted complications and infusion reactions (e.g., nausea, vomiting, adjustments in blood strain, allergies or anaphylaxis) and there have been causes to suspect the trial had significantly overstated its minimal advantages.

Remarkably, regardless of widespread protest towards the third drug, the FDA’s new advisory panel voted unanimously in favor of it, though it had a really related mechanism, efficacy, and toxicity to the beforehand unanimously rejected amyloid drug.

It ought to due to this fact come as no shock that, when the British Medical Journal carried out an impartial investigation, it discovered that, inside publicly out there databases, 9 out of 9 (assessable) members of the advisory committee had important monetary conflicts of curiosity.²⁴

Thankfully, regardless of the aggressive promotion of amyloid medicine and the business’s finest makes an attempt to advertise the sector, the market considerably acknowledged how dangerous they have been. The primary drug had its value halved (then was withdrawn as nobody wished it — making round 5 million {dollars} complete),²⁵ whereas the opposite two have had very modest gross sales (e.g., 290 million for the most well-liked one²⁶).

What Amyloids Medication Present Us

From this, 4 issues stand out:

For instance, a randomized managed trial which gave MCTs derived from coconut discovered that over 6 months,²⁷ 80% remained secure or improved — which for context, is best than what any of the amyloid drug trials confirmed, and extra importantly, doesn’t trigger mind bleeds (and prices quite a bit lower than the annual tough $30,000 price for these medicine).

Word: Quite a few readers have shared that coconut oil improved their relative’s dementia.

Likewise, only a few are conscious of a 2022 examine that ought to have revolutionized all the Alzheimer’s discipline:²⁸

Word: The RECODE protocol was primarily based round figuring out the underlying reason behind a affected person’s cognitive impairment (as 5 various things may cause dementia), after which offering acceptable pure therapies to handle the relevant trigger. Since then, many others have replicated its success of their sufferers.

DMSO and Dementia

Dimethyl Sulfoxide (DMSO) is a naturally occurring compound that has quite a lot of distinctive therapeutic properties that enable it to rescue tissues from dying and revive these broken from earlier accidents — finest demonstrated by a long time of proof exhibiting DMSO can heal strokes, mind bleeds, extreme concussions, and spinal wire accidents and save sufferers from a lifetime of paralysis.

As a lot of DMSO’s mechanisms instantly counteract the processes that set off dementia, I’ve acquired many accounts like these from readers:

“My uncle’s spouse has dementia and has been unable to talk for over a yr. My mother just lately visited them and informed them about DMSO. He started to present his spouse DMSO orally. After two weeks she started to speak once more.²⁹

I learn the article and commenced giving it to my 93 yr outdated mom in her juice each morning on the finish of November. She has had some type of dementia for over 15 years. Since taking the DMSO, she now not suffers with extreme sundowners. She is extra ‘with it’ and may talk and chuckle with us. Her character is again. She is crossing her legs once more and lifting her pinky finger when consuming her espresso. It’s plenty of little issues that make a distinction.

She is ready to perceive when I’m asking her to make use of the toilet. She is extra cognitive and has began coloring in her coloring books once more.³⁰

I deeply recognize your posts on DMSO. You helped deliver spontaneous interplay again into the lifetime of my father with Alzheimer’s.”³¹

Quite a few research assist these experiences:

These outcomes have additionally been replicated in people:

Conclusion

The Alzheimer’s story illustrates how medical science’s relentless give attention to commercializable merchandise has failed the nation. This have to be changed with prioritizing understanding the basis causes of the persistent diseases we face.

Thankfully, now that MAHA can set nationwide well being coverage and impartial media has damaged the media’s monopoly over the reality because of the lies we noticed all through COVID-19, an increasing number of are stepping outdoors the medical orthodoxy to pursue therapies that may really heal them. A possibility like this has by no means existed earlier than, and it’s crucial every of us brings consideration to the necessity for actual medication earlier than the window to essentially change the observe of medication closes.

Writer’s Word: That is an abridged model of an extended article which discusses the precise causes and coverings for Alzheimer’s illness and the cognitive decline which precedes it. That article, together with extra hyperlinks and references, could be learn right here. Moreover, a companion article on how DMSO treats neurological accidents (e.g., strokes, mind hemorrhages, traumatic mind accidents, spinal paralysis and developmental delay) could be learn right here.

A Word from Dr. Mercola In regards to the Writer

A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I recognize AMD’s distinctive perception on a variety of subjects and am grateful to share it. I additionally respect AMD’s want to stay nameless since AMD remains to be on the entrance strains treating sufferers. To search out extra of AMD’s work, make sure to try The Forgotten Aspect of Drugs on Substack.

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